PATHOPHYSIOLOGY OF THE IMMUNE SYSTEM:
- Development and organization of the immune system
- Primary and secondary lymphoid organs
- Leukocyte formula
- Innate immunity and acquired immunity
- Antigens and Aptenes
- Development and specific functions of T and B lymphocytes
- Humoral immunity and cell-mediated immunity
- Antibodies: structure and classification
- Immunopathology: hypersensitivity, allergic phenomena, autoimmune diseases.
- Examples of connective and musculoskeletal diseases on an immune and autoimmune basis.
PATHOPHYSIOLOGY OF ERYTHROPOIESIS:
- Structure and functions of hematopoietic bone marrow, effects of erythropoietic hormone (EPO) and other growth factors on hematopoiesis.
- The metabolism of iron and vitamins necessary for erythropoiesis.
Anemia definition and classification
- Physiopathological mechanisms responsible for anemias.
- Central and peripheral compensatory mechanisms of anemia. Polycythemias.
PATHOPHYSIOLOGY OF HEMOSTASIS AND COAGULATION:
- Endothelium, platelets and plasma factors in the haemostatic and coagulative process.
- The main haemorrhagic disorders due to defects of the endothelium, platelets and plasma coagulation factors (hemophilias).
- Hematoma, ecchymosis. The complications of hemorrhagic diseases.
MUSCLE-SKELETAL DISEASES (Myopathies):
Acquired and genetically based musculoskeletal alterations (mode of transmission)
- Duchenne / Becker dystrophy, Cystoid dystrophy;
- Toxic myopathies
- Inflammatory Myopathies: Polymyositis, Dermatomyositis, Inclusion Bodies
- Autophagic Accumulation Myopathies (vacuolar)
- Metabolic myopathies: Glycogenosis, Lipidic, Mitochondrial.
DISEASES OF CONNECTIVE TISSUES :
- Pathophysiology of connective tissue.
- Synthesis of collagen and types of collagen.
- Collagen diseases (collagenopathies), a mode of hereditary transmission.
- Forms associated with congenital metabolic alterations. The alterations affecting the extracellular matrix.
PATHOPHYSIOLOGY OF AGING:
- Theories on aging, molecular and cellular alterations related to aging, Sarcopenia.