1) Aetiology and cellular pathology: health and disease concepts, aetiology and pathogenesis. Environmental diseases: diseased caused by chemical or physical agents. Microbiologic agents and the patterns of disease caused by them. Molecular mechanisms of pathogenicity: PAMPS, PRR, DAMS.
2) Cellular damage and adaptations, reversible and irreversible cell injury: necrosis and apoptosis.
3) Body defenses against pathogen agents. The first (mechanical/physical barriers), second (innate immunity) and third line (specific immunity, cellular and antibodies) of defence, The immunodeficiency. The autoimmune diseases. The allergies.
4) Inflammatory-reparative response: aetiology and classification of acute inflammation, chemical mediators, vascular changes and exudates formation, cellular events and phagocytosis, systemic consequences and aetiopathogenesis of fever; chronic and granulomatous inflammation; reparative response: tissue repair and wound healing, fibrosis. Inflammatory diseases.
5) The physiopathology of fever and thermoregulation.
6) Tumoral transformation as proliferative disease. Molecular basis of tumoral tramsformation: oncogenes and tumor suppressor genes. The causes of cancer including chemicals and biological agents, the phenotype of the transformed cell, the genes causing and restricting cancer growth, tumor classification; carcinogenesis; epidemiology and prevention; the molecular mechanisms of tumor progression and metastatization. The relationship between cancer cells and tumoral microenvironment. Inflammation and cancer. Nutrition and cancer.
7) Causes and mechanisms of malnutrition. Molecular mechanisms of atherosclerosis, formation of atheromatous plaque and related consequences; thrombosis; embolism; infarction; hypoxia and cyanosis; oedema. Physiopathology of the gastro-intestinal tract (gastritis, ulcer, reflux gastric-esiphageal, celiac disease, Crhon disease). Mechanism of diabetes, classification and consequences.