The psychosomatic model and the interaction between mental and somatic functions. The biopsychosocial model and the interactions between macro- and micro-systems. The models of Damasio, Panksepp, and Solms. Somatic determinants of psychological health: gene-environment interactions, the immune system, proinflammatory mechanisms. Psychological determinants of somatic health: interpersonal relationships, somatosensory amplification, illness representations, abnormal illness behavior, alexithymia. Stress and health: allostatic load and immune system. Diagnostic classification in psychosomatics.